We assessed how Bifidobacterium bifidum MIMBb75 impacts symptoms of irritable bowel syndrome (IBS) in a controlled study of 122 participants.
Over four weeks, those taking MIMBb75 reported significantly reduced IBS symptoms compared to the placebo group.
With many experiencing better pain relief and improved quality of life, these findings suggest that MIMBb75 could be a valuable treatment option for IBS, showing durability with minimal side effects.
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9.5
CECT 7347 reduces IBS-D symptoms
A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome.
A randomized, double-blind, placebo-controlled trial exploring CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) revealed promising results for diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that after 12 weeks, both ES1 and HT-ES1 significantly reduced symptom severity compared to a placebo, as shown by lower IBS-Symptom Severity Scale scores.
Other improvements included better stool consistency and quality of life. This study marks a breakthrough with the first positive findings for a probiotic or postbiotic from this strain specifically for IBS-D patients.
Read More
9
Effective treatment for IBS-C
Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial.
We aimed to understand how Lacticaseibacillus rhamnosus IDCC 3201 (RH 3201) affects irritable bowel syndrome with constipation (IBS-C) through a thorough study. In a randomized, double-blind trial, 30 participants took either RH 3201 or a placebo for 8 weeks.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
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Most Useful Reviews
7.5
Improved constipation
1 people found this helpful
The quality is good, the ingredients are sound, and the quantity is reasonable. After consulting my doctor, I feel it has improved my constipation and bowel movements significantly.
Read More
7.5
Elevates mood
1 people found this helpful
It worked for me. Other probiotics regulated my bowel dysfunction, but Mood+ notably lifted my spirits. I realised this when my local shop stopped carrying it, and I switched to another probiotic, missing the mood-enhancing benefits. I found it online again.
Read More
7.5
Adjusts mood
An excellent product that helps to balance mood, bowel movements, and colon health.
This randomized, single-blinded trial evaluated the impact of probiotics, specifically Lactobacillus acidophilus and plantarum, on patients with diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
Read More
9.5
Effective probiotic IBS treatment
Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial.
This randomized, single-blinded trial evaluated the impact of probiotics, specifically Lactobacillus acidophilus and plantarum, on patients with diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
Read More
9.5
Bifidobacterium bifidum improves IBS symptoms
Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study.
We assessed how Bifidobacterium bifidum MIMBb75 impacts symptoms of irritable bowel syndrome (IBS) in a controlled study of 122 participants.
Over four weeks, those taking MIMBb75 reported significantly reduced IBS symptoms compared to the placebo group.
With many experiencing better pain relief and improved quality of life, these findings suggest that MIMBb75 could be a valuable treatment option for IBS, showing durability with minimal side effects.
Read More
9.5
CECT 7347 reduces IBS-D symptoms
A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome.
A randomized, double-blind, placebo-controlled trial exploring CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) revealed promising results for diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that after 12 weeks, both ES1 and HT-ES1 significantly reduced symptom severity compared to a placebo, as shown by lower IBS-Symptom Severity Scale scores.
Other improvements included better stool consistency and quality of life. This study marks a breakthrough with the first positive findings for a probiotic or postbiotic from this strain specifically for IBS-D patients.
Read More
9
Lactobacillus drink benefits IBS-C
Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink.
We explored the impact of a Lactobacillus-containing cultured milk drink on individuals with constipation-predominant irritable bowel syndrome (IBS-C). Over 30 days, participants consumed this drink daily while we assessed their clinical symptoms and inflammatory markers.
Impressively, 97.4% reported improvement in symptoms, along with noticeable reductions in intestinal transit time and fecal pH. Evidence also showed lowered levels of pro-inflammatory cytokines in IBS-C participants, supporting potential adjunctive benefits of this treatment for IBS-C patients.
The quality is good, the ingredients are sound, and the quantity is reasonable. After consulting my doctor, I feel it has improved my constipation and bowel movements significantly.
Read More
7.5
Elevates mood
1 people found this helpful
It worked for me. Other probiotics regulated my bowel dysfunction, but Mood+ notably lifted my spirits. I realised this when my local shop stopped carrying it, and I switched to another probiotic, missing the mood-enhancing benefits. I found it online again.
Read More
7.5
Adjusts mood
An excellent product that helps to balance mood, bowel movements, and colon health.
Read More
6
Smooth bowel movements
High quality! I saw someone recommend a very professional brand online. While I don't have strong feelings about this aspect, my bowel movements have been smooth, and the capsules are easy to take. I can open the capsule, soak the powder in water, and it doesn't taste odd.
Read More
7.5
Improves mood
1 people found this helpful
If we have problems with the intestines, then we also face issues with the head. Therefore, probiotics enhance bowel function and help maintain a positive mood while minimising stress.
Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder characterized by a range of symptoms including abdominal pain, bloating, gas, and altered bowel habits, which can manifest as diarrhea, constipation, or a combination of both. The exact cause of IBS isn't fully understood, but it's believed to stem from a complex interplay of factors including gut sensitivity, changes in gut motility, and psychosocial elements such as stress or anxiety. IBS is often classified into different types based on the predominant symptoms, such as IBS with diarrhea (IBS-D), IBS with constipation (IBS-C), and a mixed type (IBS-M).
Managing IBS can be multifaceted, often requiring a tailored approach based on individual symptoms and triggers. Dietary changes are frequently recommended, including low-FODMAP diets, which involve reducing fermentable carbohydrates that can exacerbate symptoms. In addition to dietary adjustments, stress management techniques and medications aimed at addressing specific symptoms, such as anti-diarrheal agents or laxatives, may also be beneficial. Since IBS can significantly impact quality of life, consulting with a healthcare provider or a registered dietitian is essential for developing an effective management plan.
Probiotics are live microorganisms, primarily bacteria, that are intended to provide health benefits when consumed in adequate amounts. These beneficial bacteria are often referred to as "good" or "friendly" bacteria because they help maintain a balanced gut microbiome, which plays a vital role in digestion, immune function, and overall health. Probiotics can be found in various foods such as yogurt, kefir, sauerkraut, and kombucha, as well as in dietary supplements. The most common strains include Lactobacillus and Bifidobacterium, which have been studied for their positive effects on gastrointestinal health, including the alleviation of symptoms related to irritable bowel syndrome (IBS) and diarrhea.
Incorporating probiotics into your diet may help support a healthy gut by competing with harmful bacteria and promoting a more diverse microbiome. However, it's important to note that the specific effects of probiotics can vary widely depending on the strain, dosage, and individual health conditions. While many people may benefit from including probiotics in their diet, it's advisable to consult a healthcare professional before starting any new supplement regimen, especially if you have underlying health issues or concerns. For those looking to explore the world of probiotics, it’s worth experimenting with various sources to find what works best for your body.
Probiotics may offer some benefits for individuals suffering from Irritable Bowel Syndrome (IBS), although results can vary from person to person. Research indicates that certain strains of probiotics can help alleviate symptoms such as bloating, gas, and changes in bowel habits. The mechanism is thought to involve the modulation of gut bacteria, which helps improve gut health and might lead to better digestion and reduced inflammation. For those with IBS, specific strains like Bifidobacterium and Lactobacillus have been examined in studies and have shown promise in reducing abdominal pain and discomfort.
However, it’s important to approach probiotic use with caution, as not all probiotics are created equal. The effectiveness often depends on the specific strain and the dosage. A well-formulated probiotic supplement, combined with a diet tailored to IBS needs, could provide additional support. It's advisable for individuals considering probiotics for IBS to consult with a healthcare provider to ensure that they choose the appropriate strains and dosages tailored for their unique symptoms. Overall, while probiotics may not be a cure-all for IBS, they can be a helpful tool in managing symptoms for some individuals.
Based on user reviews, individuals taking this supplement for Irritable Bowel Syndrome (IBS) often report noticing improvements in bowel function and overall well-being within a couple of weeks to two months. For instance, one user experienced significant improvements in constipation and bowel movements without specifying an exact timeframe Read Review. Another user noted that after two months of usage, both their mood and bowel movements showed improvements Read Review.
Overall, while results can vary, many users find that consistent use over several weeks leads to noticeable enhancements in both digestive and psychological health. This aligns with anecdotal evidence from other probiotics, which typically suggest a gradual realization of benefits as the body's microbiome adjusts. Therefore, patience combined with regular intake might be key to experiencing the desired effects Read Review.
Recent scientific research robustly supports the use of specific probiotic strains, particularly Lactobacillus and Bifidobacterium, for the management of Irritable Bowel Syndrome (IBS). Studies have shown that probiotics like Lactobacillus acidophilus and Bifidobacterium bifidum can significantly alleviate symptoms associated with IBS, including abdominal pain, bloating, and irregular bowel habits. For instance, one randomized trial revealed that patients consuming a combination of Lactobacillus acidophilus and plantarum experienced improved symptoms compared to those on placebo, with many reporting complete remission after 12 weeks of treatment [2]. Another study focused on Bifidobacterium bifidum established that 68% of participants reported significant symptom relief, underscoring the efficacy of this probiotic in managing IBS [16].
Further evaluations indicate that not only do these probiotics facilitate symptom relief, but they may also improve overall quality of life for individuals suffering from IBS. For instance, a trial demonstrated significant improvements in IBS severity and patient satisfaction among those taking Lactobacillus rhamnosus [12]. Moreover, synbiotics (a mix of probiotics with prebiotics) have been shown to enhance gut health and symptom relief, particularly in diarrhea-predominant IBS patients [4]. Collectively, these findings point towards a promising role for probiotics as a beneficial adjunct in the management of IBS, though individual responses may vary, warranting further investigation into optimal strains and formulations for different patient profiles.
Based on user reviews, many individuals report significant improvements in both digestive and psychological symptoms after taking the probiotic. Users frequently mention enhanced bowel movements, describing their experience as smoother and more regular. For instance, one user highlighted that the product significantly improved their constipation and bowel movements after consulting their doctor Read Review. Another found that the probiotic not only regulated bowel function but also notably lifted their spirits, reinforcing the link between gut health and emotional well-being Read Review.
Additionally, several reviewers pointed to an overall balance in mood, denoting a decrease in anxiety and stress alongside digestive relief. One user described it as a fantastic probiotic for both bowel regulation and anxiety reduction, while another noted improvements in mood under work pressure after consistent use over two months Read Review. While individual results can vary, the consensus suggests a recurrent benefit tied to both digestive health and mood enhancement, encouraging prospective users to give it time and regular intake to see similar results.
Users report positive experiences when combining this supplement with other probiotic products for managing Irritable Bowel Syndrome (IBS). Many have found that this supplement not only effectively regulates bowel function but also enhances mood, creating a beneficial dual-effect. For instance, one user expressed how this product notably lifted their spirits compared to other probiotics, emphasizing the importance of mood regulation alongside digestive health Read Review.
Several users also noted the interconnectedness of gut and mental health, claiming that improving their bowel function seemed to have a direct positive impact on their mood and stress levels. A review highlighted that improved bowel regulation often leads to a decreased sense of anxiety and a more positive mindset Read Review. Overall, the feedback suggests that users have found this supplement effective as part of a broader approach to IBS management, particularly regarding the overall health of their mind and gut Read Review.
Based on user reviews, it appears that the right dose for probiotics in treating Irritable Bowel Syndrome (IBS) can vary, with some finding effective results even at a lower dosage. For instance, one user noted that they experienced positive effects on their digestive and bowel issues with just one capsule, which was half the recommended dose Read Review. This suggests that individuals might not need to adhere strictly to higher dosages to see improvements, making it potentially more accessible for many.
Additionally, users have reported significant benefits in bowel movements and overall wellbeing without specifying exact dosages, indicating that a tailored approach to dosing might be best. A review highlighted improvements in constipation and bowel movements after consulting a doctor, yet it did not specify the exact amount taken Read Review. Overall, it seems that while a standard recommendation exists, observing personal responses and consulting healthcare professionals could guide users to find their optimal dosage.
7.5
Improved constipation
1 people found this helpful
The quality is good, the ingredients are sound, and the quantity is reasonable. After consulting my doctor, I feel it has improved my constipation and bowel movements significantly.
6
Smoother bowel movement
After two months of usage, I’ve seen improvements in my mood. It’s effective under work pressure and has made my bowel movements smoother.
7.5
Elevates mood
1 people found this helpful
It worked for me. Other probiotics regulated my bowel dysfunction, but Mood+ notably lifted my spirits. I realised this when my local shop stopped carrying it, and I switched to another probiotic, missing the mood-enhancing benefits. I found it online again.
7.5
Improves mood
1 people found this helpful
If we have problems with the intestines, then we also face issues with the head. Therefore, probiotics enhance bowel function and help maintain a positive mood while minimising stress.
6
Reduces anxiety
1 people found this helpful
A fantastic probiotic for regulating my bowels, but it also assists in reducing anxiety.
6
Helps digestion
It's a good one. It aids in addressing digestive and bowel issues even with just one capsule, half the recommended dose. I'd certainly purchase it again!
9.5
Effective probiotic IBS treatment
Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial.
This randomized, single-blinded trial evaluated the impact of probiotics, specifically Lactobacillus acidophilus and plantarum, on patients with diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
8
Probiotics help relieve IBS symptoms
Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial.
We investigated the impact of multispecies probiotics, including Lactobacillus acidophilus, in treating irritable bowel syndrome (IBS). In a randomized, double-blind study with 49 participants, those taking probiotics experienced significantly more symptom relief than those on a placebo after four weeks.
The probiotics not only eased abdominal discomfort and bloating but also positively altered gut bacteria. Our findings suggest that multispecies probiotics could be a valuable option for managing IBS symptoms.
7
Probiotics modestly improve IBS
Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study.
We examined the effects of a combination of Lactobacillus acidophilus CL1285 and other probiotics compared to a placebo in treating irritable bowel syndrome (IBS). Over 12 weeks, 113 participants reported significant improvements in abdominal pain, stool consistency, and overall quality of life.
Interestingly, those with diarrhea-predominant IBS and female participants noticed the most benefits. Though there were some mild adverse effects, serious issues were not reported. Overall, while some gains were observed, pain intensity and a few symptom relief measures did not show substantial improvement.
8
Probiotics show promise for IBS relief
Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study.
We evaluated the efficacy of quadruple-coated probiotics in patients with irritable bowel syndrome (IBS). One hundred and nine participants were randomly assigned to either the probiotic or placebo group for four weeks.
Participants recorded their symptoms, and we noted a significant improvement in overall IBS symptoms, particularly in female and constipation-predominant patients. The results were promising, suggesting that these probiotics can provide relief. However, further studies are needed to explore why women respond differently to this treatment.
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Barbaro MR, Bianco F, Cremon C, Marasco G, Stanghellini V, et al. A Probiotic Mixture of LR 32, BL 04, and BB 536 Counteracts the Increase in Permeability Induced by the Mucosal Mediators of Irritable Bowel Syndrome by Acting on Zonula Occludens 1. Int J Mol Sci. 2025;26. doi:10.3390/ijms26062656
Gąsiorowska A, Romanowski M, Walecka-Kapica E, Kaczka A, Chojnacki C, et al. Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides in Patients with Irritable Bowel Syndrome-A Randomized, Double-Blind, Placebo-Controlled Study. J Clin Med. 2024;14. doi:10.3390/jcm14010006
Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x
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Bonfrate L, Di Palo DM, Celano G, Albert A, Vitellio P, et al. Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients. Eur J Clin Invest. 2020;50:e13201. doi:10.1111/eci.13201
Ding FCL, Karkhaneh M, Zorzela L, Jou H, Vohra S. Probiotics for paediatric functional abdominal pain disorders: A rapid review. Paediatr Child Health. 2019;24:383. doi:10.1093/pch/pxz036
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Hojsak I. Probiotics in Functional Gastrointestinal Disorders. Adv Exp Med Biol. 2019;1125:121. doi:10.1007/5584_2018_321
Han X, Lee A, Huang S, Gao J, Spence JR, et al. Lactobacillus rhamnosus GG prevents epithelial barrier dysfunction induced by interferon-gamma and fecal supernatants from irritable bowel syndrome patients in human intestinal enteroids and colonoids. Gut Microbes. 2019;10:59. doi:10.1080/19490976.2018.1479625
Wegh CAM, Benninga MA, Tabbers MM. Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review. J Clin Gastroenterol. 2018;52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017:S10. doi:10.1097/MCG.0000000000001054
Darbaky Y, Evrard B, Patrier S, Falenta J, Garcin S, et al. Oral probiotic treatment of Lactobacillus rhamnosus Lcr35 prevents visceral hypersensitivity to a colonic inflammation and an acute psychological stress. J Appl Microbiol. 2017;122:188. doi:10.1111/jam.13320
Cruchet S, Furnes R, Maruy A, Hebel E, Palacios J, et al. The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. Paediatr Drugs. 2015;17:199. doi:10.1007/s40272-015-0124-6
Chung HG, Min YW, Lee C, Hong SN, Won JY, et al. Effects of Novel Probiotics in a Murine Model of Irritable Bowel Syndrome. Korean J Gastroenterol. 2020;75:141. doi:10.4166/kjg.2020.75.3.141
Ruiz-Sánchez C, Escudero-López B, Fernández-Pachón MS. Evaluation of the efficacy of probiotics as treatment in irritable bowel syndrome. Endocrinol Diabetes Nutr (Engl Ed). 2024;71:19. doi:10.1016/j.endien.2024.01.003
Tomita T, Fukui H, Okugawa T, Nakanishi T, Mieno M, et al. Effect of G9-1 on the Intestinal Environment and Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)-like Symptoms in Patients with Quiescent Crohn's Disease: A Prospective Pilot Study. J Clin Med. 2023;12. doi:10.3390/jcm12103368
Andresen V, Gschossmann J, Layer P. Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. Lancet Gastroenterol Hepatol. 2020;5:658. doi:10.1016/S2468-1253(20)30056-X
Guglielmetti S, Mora D, Gschwender M, Popp K. Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2011;33:1123. doi:10.1111/j.1365-2036.2011.04633.x
Hong KS, Kang HW, Im JP, Ji GE, Kim SG, et al. Effect of probiotics on symptoms in korean adults with irritable bowel syndrome. Gut Liver. 2009;3:101. doi:10.5009/gnl.2009.3.2.101
Williams EA, Stimpson J, Wang D, Plummer S, Garaiova I, et al. Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. Aliment Pharmacol Ther. 2009;29:97. doi:10.1111/j.1365-2036.2008.03848.x
Martin FP, Cominetti O, Berger B, Combremont S, Marquis J, et al. Metabolome-associated psychological comorbidities improvement in irritable bowel syndrome patients receiving a probiotic. Gut Microbes. 2024;16:2347715. doi:10.1080/19490976.2024.2347715
Srivastava S, Basak U, Naghibi M, Vijayakumar V, Parihar R, et al. A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome. Gut Microbes. 2024;16:2338322. doi:10.1080/19490976.2024.2338322
Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. doi:10.1007/s12602-023-10151-w
Khoo XH, Chong CW, Talha AM, Philip K, Teh CS, et al. The impact of diet and ethnicity on gut microbiota variation in irritable bowel syndrome: A multi-center study. J Gastroenterol Hepatol. 2023;38:1259. doi:10.1111/jgh.16174
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